Most of the nightclubs are located in the central business district, especially along the Granville Street strip, south of Robson and along Water Street in Gastown. There are a number of good local pubs in the various quieter neighbourhoods of the city, such as along Main Street or Broadway. Closing times for most of these pub-like establishments begin at 1AM; nightclubs close between 2AM-3AM with a very small number operating after-hours. Nightclubs with music, a DJ and a dance floor usually charge an entrance fee. Be aware that many nightclubs often have long lineup queues on weekends, which are usually self-imposed regardless of whether or not the establishment is near capacity to attract business. Flexibility and willingness to go early is key should nightlife become part of your travel plans.
Note that liquor stores at the latest close by 11PM, while many are closed by 9PM, and there will exist no other legal options apart from drinking at an establishment beyond this time.
beer
Vancouver offers a number of destinations for beer drinkers. The largest is the Granville Island Brewery on Granville Island tours are available. Other microbreweries are housed in brewpubs, popular ones include the Yaletown Brewing Company in Yaletown and Steamworks at the entrance to Gastown. The Alibi Room, near Gastown, specializes in beers by Northwestern microbreweries.